中文
6-Prenylnaringenin (6-PN, CAS 68682-01-9) is a potent and reversible inhibitor of Cav3.2 T-type calcium channels (IC₅₀ = 991 nM), widely used in neuroscience and pharmacological research. It demonstrates exceptional blood-brain barrier permeability, making it ideal for studying neuropathic and visceral pain mechanisms.
产品名称 :
6-Prenylnaringenin (6-PN)CAS编号 :
68682-01-9外观 :
Off-white crystalline powder规格 :
1%-98%🌿 6-Prenylnaringenin (6-PN)
CAS No.: 68682-01-9
Molecular Formula: C₂₀H₂₀O₅
Molecular Weight: 340.37
✅ Potent Phytoestrogen with Dual Activity
6-PN combines estrogenic and antioxidant properties, offering dual benefits:
Endocrine Modulation: Binds selectively to estrogen receptors (ERα/ERβ), alleviating menopausal symptoms (e.g., hot flashes, osteoporosis) without systemic risks of conventional hormone therapy.
Oxidative Defense: Scavenges free radicals via prenyl group, protecting against UV-induced skin damage and lipid peroxidation.
| Parameter | Detail |
|---|---|
| Purity Range | 1%, 5%, 10%, 20%, 50%, ≥98% (HPLC) |
| Identification | HPLC-UV, NMR, MS |
| Storage | ≤20°C (protected from light) |
| Shelf Life | 24 months |
| Appearance | Off-white crystalline powder (≥98%) Light yellow powder (5%-50% blends) |
Menopausal Symptom Relief
Efficacy: Mimics natural estrogen activity, significantly reducing Kupperman Menopause Index scores (e.g., improved hot flashes, mood swings).
Safety Profile: Non-carcinogenic alternative to synthetic estrogens (e.g., conjugated equine estrogens), minimizing breast/endometrial cancer risks.
Cardiometabolic Health
Lipid Regulation: Lowers total cholesterol (TC) by 10–15% and LDL-C/HDL-C ratio, supporting cardiovascular health in postmenopausal women.
Dermatological Applications
Collagen Synthesis: Enhances skin elasticity by stimulating collagen production.
UV Protection: Synergizes with sunscreens to reduce oxidative damage in cosmeceuticals.
| Sector | Use Cases |
|---|---|
| Pharmaceuticals | - Menopausal health capsules (e.g., 20–50 mg/day formulations) - Osteoporosis prevention adjuvants |
| Cosmeceuticals | - Anti-aging serums (0.5–2% concentration) - Antioxidant-boosted sunscreens |
| Functional Foods | - Hormone-balancing beverages (1–5% liquid suspensions) - Metabolic health bars |
🔬 Science-Backed Customization
Synergistic Blends: Pre-optimized with resveratrol for enhanced bioavailability or vitamin E for oxidative stability.
Solvent-Free Extraction: Patented supercritical CO₂ method ensures >99% purity and eco-friendly production.
🌐 Certified Quality & Safety
Compliance: ISO 9001, Non-GMO Project Verified.
Contaminant Control: Heavy metals <10 ppm (USP/EP), residual solvents undetectable.
| Weight | Packaging | Transport | Delivery Time |
|---|---|---|---|
| 10g–5kg | Vacuum foil bags + desiccant | DHL/FedEx | 3–7 days |
| 5kg–25kg | Gas-flushed food-grade buckets | Air freight | 5–10 days |
| >25kg | Fiber drums (ISO-certified) | Sea freight | 15–45 days |
Q: How is quality verified before ordering?
A: Free samples (1–20g) provided with batch-specific Certificate of Analysis (COA) detailing purity, heavy metals, and microbial limits.
Q: What is the minimum order quantity (MOQ)?
A: 10g for ≥98% purity, 1kg for blends (5–50%).
Q: Can you support custom formulations?
A: Yes! OEM services include pH-adjusted solutions (pH 3–7), solubility-enhanced emulsions, or blend optimization.
Q: Are regulatory documents available?
A: Full dossier (Specs, SDS, Non-GMO/Allergen Statements) compliant with FDA, EFSA, and COSMOS standards.
End-to-End Traceability: Sourced from EU-certified organic hops (Alpine regions), with blockchain-supported supply chain visibility.
R&D Collaboration: Co-develop application-specific formulations backed by clinical data on estrogenic activity and safety.
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6-Prenylnaringenin (6-PN, CAS 68682-01-9) is a potent and reversible inhibitor of Cav3.2 T-type calcium channels (IC₅₀ = 991 nM), widely used in neuroscience and pharmacological research. It demonstrates exceptional blood-brain barrier permeability, making it ideal for studying neuropathic and visceral pain mechanisms.
阅读更多
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