Ruscogenin 98% Supplier: CAS 472-11-7, HPLC Purity & Bulk Sourcing Guide

Quick Answer

Ruscogenin (CAS 472-11-7) is a steroidal sapogenin obtained primarily from Ruscus aculeatus (butcher's broom) root. When sourcing Ruscogenin 98%, verify four things before ordering: a batch-specific HPLC chromatogram, the botanical source statement, identity confirmation data (MS/NMR or IR), and storage-relevant documentation. Because the material is a purified single compound with a defined melting range, identity and purity can be checked analytically — which is why buyers should insist on real batch data rather than a template COA.

Key Takeaways

· Ruscogenin is a steroidal sapogenin (C₂₇H₄₂O₄, MW 430.63), not a standardized plant extract — the two are different products with different price logic.

· ≥98% HPLC is the common high-purity specification used in ingredient development and research applications.

· Request batch COA + actual HPLC chromatogram + MS/NMR data; confirm the batch number on the documents matches your shipment.

· Storage at 2–8 °C, light-protected, matters: ruscogenin is sensitive to prolonged air and light exposure.

· Solubility in water is low; formulations typically rely on ethanol- or glycol-based systems — confirm the grade and presentation with your supplier early.

· Documentation expectations differ by market; for US-bound cosmetic or research supply, confirm the intended use with your regulatory team.

1. Chemical Identity and Specifications

Ruscogenin belongs to the spirostane-type steroidal sapogenins. Its defined melting range and single-compound nature make it practical to verify identity by melting point determination, IR, or MS, in addition to HPLC purity — a useful cross-check when evaluating a new supplier.

2. Ruscogenin 98% vs. Standardized Butcher's Broom Extract

Buyers frequently compare quotations for products that are not equivalent:

If your specification calls for "98% ruscogenin", a 10%–30% standardized extract will not satisfy it, regardless of the price difference. Confirm the analytical basis in writing before comparing costs.

3. HPLC and COA Verification: What to Check

A credible Ruscogenin 98% batch file should include:

1. Batch-specific HPLC chromatogram — with column type, mobile phase, detection wavelength, and integration parameters, not just a percentage.

1. Identity confirmation — MS and/or NMR data supporting the spirostane structure; melting point within 182–186 °C is a quick secondary check.

1. Impurity profile — related sapogenins and process-related impurities, reported or stated as within specification.

1. Residual solvents and heavy metals — results should match the requirement set applicable to your market and intended use.

1. SDS and TDS — consistent with the COA and current for the grade supplied.

1. Batch traceability — the batch number on the COA must match the labels on the drums you receive.

A practical procurement sequence: request a 20 g sample with the full documentation package, run independent HPLC verification at a third-party laboratory, then scale to commercial quantities. CQ HERB supports this sample-first evaluation model with batch-specific documentation.

4. Solubility, Formulation Handling and Stability

Ruscogenin is poorly water-soluble, which shapes how formulators work with it:

· Solvent systems: ethanol, glycol, or DMSO-based premixes are common in development work; confirm compatibility with your final system early.

· Thermal exposure: keep processing temperatures well below the melting range and avoid prolonged heat during incorporation.

· Light and air: the material should be handled in closed containers, protected from light; long exposure to air reduces content over time.

· Storage: 2–8 °C, dry, light-protected. Shelf life is typically stated as 36 months under recommended conditions; check the retest date on the COA.

· Shipping: for warm-climate destinations, confirm insulated packaging and transit documentation with your supplier — heat exposure during transit is a common, avoidable quality issue.

5. Intended Applications and Regulatory Context

Ruscogenin 98% is supplied for:

· Cosmetic raw-material development — used by formulators as a botanical-derived active ingredient in skin and body care development; finished-product claims are the responsibility of the brand and must comply with the applicable cosmetic regulation in the destination market.

· Research and analytical applications — as a reference compound for phytochemical, chromatographic, and natural-product research.

Regulatory note: permitted use, labeling, and claim language for ruscogenin-containing products differ by market. US-bound supply may fall under cosmetic ingredient or research-material frameworks depending on intended use and how the material is presented; buyers should confirm the applicable pathway with their regulatory team. CQ HERB supplies the ingredient with technical documentation — it is not a finished product and carries no product claims.

6. Supplier Evaluation Checklist

· Batch-specific HPLC chromatogram provided

· MS/NMR or IR identity data available

· Melting range stated and consistent with specification

· Heavy metals and residual solvents reported

· Botanical source and extraction process described transparently

· COA / SDS / TDS internally consistent

· Sample available for third-party verification

· Cold-chain or insulated shipping arranged for warm destinations

· Multi-batch supply stability and lead-time transparency

Nanjing Spring & Autumn Biological Engineering Co., Ltd. (CQ HERB) supplies Ruscogenin 98% with batch-based documentation including COA, HPLC analytical data, MS/NMR, SDS and TDS, and supports sample evaluation before bulk orders. Our quality management system is certified to ISO 9001.

7. Bulk Ordering Practicalities

· Sample stage: 5 g with full documentation, suitable for independent verification.

· Development quantities: 25 g–100 g for pilot formulation work.

· Commercial quantities: 500 g–1 kg and above, scheduled against forecast; larger volumes quoted on request.

· Packaging: sealed, moisture-barrier inner packaging in outer drums; cold-chain or insulated options for warm-climate destinations.

· Lead time: confirm current stock and production schedule at quotation.

FAQ

Q: What is the CAS number of Ruscogenin? A: CAS 472-11-7; molecular formula C₂₇H₄₂O₄; molecular weight 430.63 g/mol.

Q: Is Ruscogenin the same as butcher's broom extract? A: No. Ruscogenin is a single purified steroidal sapogenin; butcher's broom extract is a complex botanical preparation that may be standardized to a stated ruscogenin content.

Q: What purity should I specify? A: ≥98% HPLC is the common high-purity grade for ingredient development and research use. Standardized extracts are a separate product category.

Q: How should Ruscogenin 98% be stored? A: 2–8 °C, dry, protected from light, in tightly closed containers. Refer to the SDS/TDS for the specific grade.

Q: Can I receive a sample before a bulk order? A: Yes. CQ HERB provides 20 g samples with batch-specific documentation so buyers can complete independent verification first.

Q: Does Ruscogenin dissolve in water? A: Solubility in water is low. Ethanol, glycol, or DMSO-based systems are typically used in development work; discuss your formulation format with the supplier.

Conclusion

Sourcing Ruscogenin 98% comes down to verification discipline: confirm you are comparing a purified compound against a standardized extract, audit the batch-specific HPLC and identity data, plan for low water solubility and cool, light-protected storage, and validate the regulatory pathway for your market and intended use. A supplier that provides real batch documentation and sample-first evaluation removes most of the risk from the purchase.

Related reading: Ruscogenin (CAS 472-11-7): A High-Purity Steroidal Sapogenin for Advanced Research · Natural Active Compounds · Cosmetic Active Ingredients

Contact CQ HERB for Ruscogenin 98% specifications, samples, and bulk supply inquiries — Ives Shen, International Sales Dept. · sale05@cqherb.com · www.cqherb.com