High-Purity Baohuoside I CAS 113558-15-9 Research-Grade Flavonoid

Baohuoside I (CAS: 113558-15-9)

Plant Source: Epimedium brevicornum Maxim. (Barrenwort)
Molecular Formula: C₂₇H₃₀O₁₀

Molecular Weight: 514.5 g/mol
Purity: ≥98% (HPLC-validated)
Appearance: Light yellow to yellow crystalline powder

Chemical & Physical Properties

Product Specifications

CAS No.: 113558-15-9

Synonyms: Icariside II, Anhydroicaritin, Baohuoside I

Purity: ≥98% (HPLC, UV detection at 270 nm) 

Packaging: 20 mg, 100 mg, 500 mg, 1 g，10g，100g，1kg (custom bulk available)

Stability: Stable for 2 years under recommended storage; avoid freeze-thaw cycles in solution 

Biological Activities & Mechanisms

In Vitro & In Vivo Efficacy

Anti-Cancer Activity:

Inhibits CXCR4 chemokine receptor (IC₅₀: 12–25 μM), suppressing invasion of cervical and breast cancer cells.

Induces apoptosis in non-small cell lung cancer (A549) via ROS-mediated JNK/p38 MAPK activation and caspase cascade inhibition (IC₅₀: 9.6–25.1 μM) .

Blocks esophageal squamous carcinoma (Eca109) growth (IC₅₀: 4.8 μg/mL at 48 h) by downregulating β-catenin, cyclin D, and survivin.

 Anti-Metastatic Effects:

 Suppresses CXCL12-induced cancer cell invasion by dose-dependent inhibition of NF-κB signaling.

 Osteoprotective Action:

Mitigates glucocorticoid-induced osteoporosis in zebrafish models by enhancing osteoblast activity.

Clinical & Research Applications

Oncology: Therapeutic candidate for lung, breast, cervical, and esophageal cancers via CXCR4/NF-κB targeting.

Bone Health: Potential agent against osteoporosis by promoting bone formation.

Synergistic Therapy: Enhances efficacy of 5-FU in apoptosis induction by modulating Bcl-2/Bax expression.

 Experimental Protocols

Cell-Based Assays:

Use in DMSO at 10–25 μM working concentrations (MTT assay for viability).

Centrifuge vials before reconstitution to prevent compound adhesion .

Animal Studies:

Tumor xenograft models: 25 mg/kg intralesional injection in nude mice, significant suppression of cyclin D1/survivin.

Ordering & Support

Quality Assurance: Batch-specific HPLC, MS, NMR reports provided. 

Customization: Bulk quantities (up to kg-scale), extraction from Epimedium spp. upon request.

Shipping: Ambient temperature (powder); dry ice for solutions.